Chop mushroom stems finely. In a bowl, mix cream cheese, spinach, artichokes, chopped stems, mozzarella, half the Parmesan, garlic, red pepper flakes, salt, and pepper.
Spray mushroom caps with cooking spray and season with salt and pepper.
Fill each mushroom cap generously with the spinach artichoke mixture and sprinkle with remaining Parmesan.
Place stuffed mushrooms in air fryer basket. Air fry at 370°F for 10-12 minutes until mushrooms are tender and tops are golden.
Let cool for 2 minutes before serving. Serve warm.