Set up a breading station: flour with salt and garlic powder in one dish, beaten eggs in a second dish, and panko breadcrumbs in a third dish.
Dredge each chicken tenderloin in seasoned flour, shake off excess, dip in egg, then press firmly into the panko breadcrumbs to coat on all sides.
Preheat the air fryer to 390F. Spray the basket with cooking spray. Arrange the breaded tenders in a single layer without overcrowding and spray the tops lightly. Air fry for 10-12 minutes, flipping once halfway, until golden brown and cooked through.
While the chicken cooks, whisk together the honey, adobo sauce, melted butter, and lime juice until smooth and glossy.
Brush or drizzle the honey chipotle sauce generously over the hot tenders as soon as they come out. Serve immediately with extra sauce on the side for dipping.