In a large bowl, combine the shredded chicken, black beans, corn, mexican blend cheese, softened cream cheese, salsa, cumin, chili powder, garlic powder, and salt. Mix everything together until evenly combined.
Warm the flour tortillas in the microwave for about 15 seconds to make them pliable. Divide the filling evenly among the 4 tortillas, placing it in the center of each one.
Fold in the sides of each tortilla, then roll them up tightly from the bottom like a burrito, tucking the edges in as you go. Make sure the seams are sealed well.
Preheat the air fryer to 380°F (193°C) for 3 minutes.
Place the chimichangas seam-side down in the air fryer basket. Spray all sides generously with cooking spray.
Air fry at 380°F for 8 to 10 minutes, flipping halfway through and spraying again with cooking spray, until the tortillas are golden brown and crispy on all sides.
Let them rest for 2 minutes, then serve with sour cream and guacamole.